Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,711 – 4,725 of 60,549 results

4,711

Cayman Chemical SNAP 94847, Purity: ≥98%, CAS: 487051-12-7, 25 mg

An antagonist of MCH1 (Ki = 2.2 nM for the recombinant rat receptor); selective for MHC1 over α1A-adrenergic and dopamine D2 receptors (Kis = 180 and 7,400 nM, respectively, for the recombinant human receptors); increases the time mice spend in the light side of the light/dark exploration test at 20 mg/kg; reduces food intake and body weight, as well as plasma levels of glucose, insulin, and triglycerides, in a mouse model of high-fat diet-induced obesity at 5 mg/kg in combination with rimonabant

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4,712

Medchemexpress LLC N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG

N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG

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4,713

Medchemexpress LLC 3-isopropylphenyl diphenyl phosphate | 69515-46-4 | MFCD30718732 | 368.36 | C21H21O4P | 25mg

3-Isopropylphenyl diphenyl phosphate is a flame retardant

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4,714

Apexbio Technology LLC BMS-599626 Hydrochloride 873837-23-1 100mg

BMS-599626 Hydrochloride (CAS 873837-23-1) is a selective small-molecule inhibitor targeting the human epidermal growth factor receptors HER1 (EGFR) and HER2 exhibiting IC50 values of 22 nM and 32 nM respectively By antagonizing these receptor tyrosine kinases BMS-599626 disrupts downstream signaling pathways involved in cellular proliferation and survival In vitro the compound inhibits proliferation of breast tumor cell lines overexpressing HER1 or HER2 but shows limited effects on cells lacking these receptors In vivo oral administration in murine xenograft models suppresses tumor growth in a dose-dependent manner BMS-599626 is valuable for studying HER-mediated oncogenic signaling and targeted therapy development

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4,715

Cayman Chemical SB-242235, Purity: ≥98%, CAS: 193746-75-7, 25 mg

A p38α MAPK inhibitor (IC50 = 0.019 µM); selective for p38α MAPK over a panel of 10 kinases, including ERK2, JNK1, EGFR, and C-RAF (IC50s = >10 µM for all); inhibits IL-1α-induced production of NO in bovine articular cartilage explants (IC50 = ~1 µM); inhibits increases in epidermal COX-2 levels and erythema in mice exposed to UVB irradiation at 100 mg/kg; reduces paw edema in a rat model of adjuvant-induced arthritis at 10, 30, and 60 mg/kg

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4,716

Cayman Chemical A-771726, Purity: ≥98%, CAS: 163451-81-8, 25 mg

An active metabolite of leflunomide; inhibits DHODH (IC50 = 0.23 µM); inhibits the production of PGE2 in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively); inhibits the proliferation of isolated human PBMCs at 25 and 100 µM; delays disease onset and decreases neurological deficits in a rat model of EAE induced by CFA and M. tuberculosis at 3 and 10 mg/kg

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4,717

Apexbio Technology LLC Choline Fenofibrate 10mg

A3308 is a small molecule designed for biomedical research applications though detailed structural and registry data are currently unavailable Its mechanism of action centers on modulating specific cellular pathways enabling the investigation of signaling events critical to various physiological and pathological processes A3308 s utility is primarily as a research tool to elucidate molecular targets and cellular responses supporting studies in signal transduction pathway characterization and potential therapeutic target identification

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4,718

TARGETMOL CHEMICALS INC RN-1734 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 uM5.9 uM3.2 uM for hTRPV4 mTRPV4 and rTRPV4respectively)purity: 98%

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4,719

Sigma Aldrich Fine Chemicals Biosciences Azelastine Related Compound B United States Pharmacopeia (USP) Reference Standard | 117078-69-0 | 20MG

Azelastine Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 283.8 | 117078-69-0 | 20MG

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4,720

Cayman Chemical GSK2837808A, Purity: ≥98%, CAS: 1445879-21-9, 5 mg

A potent inhibitor of LDHA and LDHB (IC50s = 2.6 and 0.43 nM, for human recombinant LDHA and LDHB, respectively); inhibits lactate production in Snu398 hepatocellular carcinoma cells in which LDHB expression is undetectable (EC50 = 400 nM); reduces glucose consumption in Snu398 but not HepG2 cells; 30 cancer cell lines show differential sensitivities to GSK2837808A (EC50s from 400 nM to 30 µM); potency does not correlate with LDHA, LDHB, or total LDH expression levels

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4,721

TARGETMOL CHEMICALS INC FERULOYLPUTRESCINE 25MG

Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Feruloylputrescine is a natural product. purity: 98%

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4,722

Selleck Chemical LLC Argpressin Acetate 50mg 113-79-1 Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2(Cys1-Cys6)

Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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4,723

STEMCELL Technologies Dasatinib, Size: 10 mg

Selectively inhibit SRC/ABL kinases, such as ABL, SRC, LCK, and YES with Dasatinib (Lombardo et al. J Med Chem, 2004; Davis et al. Nat Biotechnol, 2011). This tyrosine kinase inhibitor inhibits proliferation in cell lines derived from chronic myeloid leukemia (CML), prostate, breast, and colon tumors (Lombardo et al. J Med Chem, 2004; Davis et al. Nat Biotechnol, 2011); induces cell-cycle arrest and apoptosis and decreasing growth in thyroid cancer cells (Chan et al. Clin Cancer Res, 2012); and inhibits the production of extracellular matrix proteins in dermal fibroblasts and prevents the development of bleomycin-challenge-induced fibrosis in mice (Distler & Distler. Rheumatology, 2008; Akhmetshina et al. FASEB J, 2008). Dasatinib is supplied as a crystalline solid with ≥98% purity; Molecular weight 488.0 g/mol; CAS Number 302962-49-8. Visit STEMCELL.com for more information and related products.

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4,724

TARGETMOL CHEMICALS INC MASUPIRDINE FREE BASE 5MG

Also available in 1mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. Masupirdine free base (SUVN-502 free base) is an orally available 5-HT6 receptor antagonist that crosses the blood-brain barrier and has a Ki value of 2.04 nM for the human 5-HT6 receptor.Masupirdine free base is potent and selective with multiple targets. Masupirdine free base is highly potent selective and inhibits multiple targets.Masupirdine free base can be used in the study of neurological disorders such as Alzheimer's disease. purity: 98%

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4,725

Cayman Chemical Sisomicin, Purity: ≥95%, CAS: 32385-11-8, 100 mg

A broad-spectrum aminoglycoside antibiotic; active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa, among others (MICs = 0.01-0.75 µg/ml); protective against Gram-positive and Gram-negative bacterial infections in mice (PD50s = 0.5-6 mg/kg)

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Bioactive Small Molecules

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Medchemexpress LLC N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3-isopropylphenyl diphenyl phosphate | 69515-46-4 | MFCD30718732 | 368.36 | C21H21O4P | 25mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG

Medchemexpress LLC 3-isopropylphenyl diphenyl phosphate | 69515-46-4 | MFCD30718732 | 368.36 | C21H21O4P | 25mg